Predicting residue-residue contact maps by a two-layer, integrated neural-network method
نویسندگان
چکیده
منابع مشابه
Predicting residue-residue contact maps by a two-layer, integrated neural-network method.
A neural network method (SPINE-2D) is introduced to provide a sequence-based prediction of residue-residue contact maps. This method is built on the success of SPINE in predicting secondary structure, residue solvent accessibility, and backbone torsion angles via large-scale training with overfit protection and a two-layer neural network. SPINE-2D achieved a 10-fold cross-validated accuracy of ...
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MOTIVATION Protein residue-residue contacts continue to play a larger and larger role in protein tertiary structure modeling and evaluation. Yet, while the importance of contact information increases, the performance of sequence-based contact predictors has improved slowly. New approaches and methods are needed to spur further development and progress in the field. RESULTS Here we present DNC...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2008
ISSN: 0887-3585
DOI: 10.1002/prot.22329